![]() ![]() Whether I’m at home, a cafe, or traveling, I need to be able to access all my stuff. I work pretty much anywhere as long as there’s an internet connection. Reason 1: SynchronizationĪs I mentioned, I have at least 10 email accounts. While I love Apple, it’s native apps don’t have the necessary functionalities that power users need. That means working on it if it’s a task for you, delegate it to other people and create a follow-up action, delete/archive it, or defer it in the future. The touch-it-once method means when you open an email (touch), you have to take action on it. Inbox zero means you either delete/archive your emails so that your inbox has nothing in it. I also apply Getting Things Done (GTD) principles. I practice two principles that any productivity guru tells you: inbox zero and touch-it-once. I mentioned earlier that I stay on top of my emails. ![]() If you want to learn more, see the Spark Privacy Policy.Let me tell you why… 3 Reasons Why I Switched from Mail to Spark Mail Note: To provide you with the sync option, we encrypt the information about your accounts and preferences and store it on our secure servers. It’s better to log into Spark with your personal or work email and then add the other accounts ( Mac| iOS) For instance, the email address your company uses for customer support or client communication. Don’t use the email address shared between multiple people as an email for sync. We recommend you to use for sync the email account only you have access to.
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![]() Through the description of how to play, you probably also realize that in addition to moving skills, and sharp observation, the remaining important part to create victory is the Weapons. The higher you go, the stronger these attacks, the boss is also more terrible than before. If successful, you will get a lot of bonus points and prepare for a new wave of enemies. You have to constantly avoid the attacks launched from it, not touch it, and have to deploy a lot of high-performance bullets thrown at the boss to hope to defeat it. How to fight this boss? Boss is both huge, fierce, and constantly moving to crash and explode your planet. Your job is to pin down this boss to pass a new wave of more attractive and challenging. Up to a certain limit specified by the game, the wave will pass, but a giant Boss will appear. Each time you kill a monster, you will gain points. Turretz is not divided into specific levels, but into waves of monster attacks. But it also brings a big challenge for players: aiming is not something you want to do now. This just makes the difference is to diversify the direction of fire and increasing the wide range of attacks from our side. The special feature of the planets is that they always rotate, so when you place the missile on the surface and start shooting at the enemy, the bullet will also radiate in many different directions. The planet has its own powerful attacks depending on the player’s skills. Of course, our planet never lets monsters rampage. During the game, if you are continuously hit, your health will gradually decrease to 0, and your planet will explode, and game over. Sometimes these attacks take place separately, but then they will increase in number, continuously becoming large waves crashing down on your planet.Įach planet will have a certain amount of stamina. Continuously dodge collisions or enemy attacks. To control the planet, you will touch the screen in the countries to move in the right direction. It uses single ammunition, which fires automatically without triggering. In which the most basic weapon each planet has at the beginning is the Basic Turrett. In Turretz, you will control a planet moving through space, in turn destroying any oncoming threats to sweep tons of dangerous monsters, the planet needs to be equipped with some special weapons. In that context, humans always face the risk of being taken over by these creatures, you need to protect the Earth and beyond the planets from potential future habitation, guaranteeing the present and the distant future of people.Ī series of intense battles broke out, between human planets, including Earth, and creatures floating in space. Many giant homeless creatures are floating around looking for a large area to live in. BackgroundĪt some point in the vast universe, the planets were developing life. And is a game for those of you who love retro games but still want a new way of control. Sometimes there are game ideas that are not new, but it is the way of connecting every detail, breathing life into each small concept in it, that will make the whole new and much more attractive. menu_bookĪ shooting game with pixel graphics has a modern breath! But at the same time, adding new points, different contexts and ways of expressing objects make the game more vivid and modern. Turretz MOD APK recreates the classic “spaceship shooting” style from the pixel game era. ![]() ![]() ![]() Wine is a practical and free solution to try out to get the best features of both OS environments. pkg file to download Click the file to open a terminal window Start the program from there Wait until the installation is finished You can also use third-party applications like WineBottler, CrossOver for Mac, and PlayOnMac. In case you miss a few applications from your Windows PC, a compatibility layer can help fill the gap. Locate the Wine program from its official website Find the macOS version and wait for the. The easiest way to install the trading platform is download the ready-made package from the. We cannot confirm if there is a free download of this app available. Thus, your Mac will need to 'lend' part of its power to 'the other PC.' Parallels Desktop, VirtualBox, and VMware Fusion are but a few such implementations. Among all the Wine versions there is one for Mac OS. Download of Wine 7.0 for Mac was available from the developers website when we last checked. Also, virtual machines are a second computer, which needs a separate OS installation. Compatibility layers are generally used for a few apps to run on an alien environment. While Wine is convenient with easy integration, it might not suit your needs. What are other options to run Windows on Mac? The app makes it possible to run a 'desktop in a box,' DirectX and OpenGL-based games and apps. If that doesnt suit you, our users have ranked more than 25 alternatives to Wine and 13 are available for Mac so hopefully you can find a suitable replacement. The best Mac alternative is PlayOnLinux - PlayOnMac, which is both free and Open Source. Wine helps Windows apps with a large number of specific networks and devices such as voice drivers, multilingual keyboards, modems, and scanners. There are many alternatives to Wine for Mac if you are looking for a replacement. While Wine has its highs and lows, here are a few features that will improve your workflow: Open the WineBottler disk image once it has finished downloading, and then drag the Wine and WineBottler icons to your Applications folder. Although these toolsets work on the same base as Wine, they are easier to handle from a user's perspective compared to Wine's barebone operation that might need manual configuration. You can also use third-party applications like WineBottler, CrossOver for Mac, and PlayOnMac. Wait until the installation is finished.Click the file to open a terminal window.Darwine is a free and open source software application. Find the macOS version and wait for the. Wineskin Winery is a free and open-source tool for running Windows apps on Apple computers. Use Wine (Wine Is Not an Emulator) to run Windows applications on Darwin and Mac OS X.Locate the Wine program from its official website.The system should allow programs from external sources.Ensure you have XQuartz version 2.7.7 or above.Please, FOLLOW the Step-by-step instructions. PICK THIS VERSION and READ the instructions about skipping the ADs, they are deliberately deceptive. XQuartz (Here is a link to a version that has been used successfully since January) You need download two pieces of software in addition UCINET: XQuartz and WineBottler ![]() ![]() Here are instructions for running UCINET with Wine. Boot Camp and the emulators work best: Wine does not allow full functionality (such as calling Excel from within UCINET, or using shortcut keys) but it is free. To run it on another platform you will need a Windows partition (such as Boot Camp), a Windows emulator (such as VMware Fusion or Parallels), or a "compatibility layer" such as Wine. ![]() ![]() But it’s likely puffins can live even longer than that it’s only relatively recently that bands durable enough to last 40 years have come into wide use. It has a black crown and back, pale grey cheek patches, and white underparts. However, in recent years breeding failures has. The Atlantic puffin is a colorful seabird and is the only puffin native to the Atlantic Ocean. Puffin Browser has not been rated by our users yet. Puffin Browser runs on the following operating systems: Windows/Mac. It was initially added to our database on. It is a highly sociable bird forming colonies of many thousands. The latest version of Puffin Browser is 9.0.1.982, released on. It has a chunky body with short wings, and a large, colourful bill with serrated edges capable of holding up to 30 fish. Puffin Browser For PC, windows & Mac chrome theme can easily change your New chrome Tab Color and New tab background. The oldest recorded Atlantic Puffin was banded as a chick in Norway and lived to be 41 years old. The Atlantic puffin is a comical looking bird sometimes nicknamed the sea parrot or clown of the sea.Half of North America’s Atlantic Puffins breed in one location: Witless Bay, Newfoundland, Canada.Price Breaks of 5 or 10 Available for when you order 72 or 144 Units. The Atlantic Puffin is the official bird of Newfoundland and Labrador, Canada. Handcrafted wooden Keyrings with quality key ring and clip.Puffins do not breed until they are 3–6 years old. The adult puffin is black on top, white below, with black cap and black collar, his legs are orange. What makes the puffin special is the colourful, flat-sided beak. And like other birds with long lifespans, the young take several years to mature. The puffin is a rather small bird, around 26-29 cm long and weights around 450-500g. Like many seabirds, the Atlantic Puffin is long-lived, averaging 30 plus years. Larger than a Dovekie, smaller than a Common Murre.Its wingspan is 47 to 63 cm (19 to 25 in) and on land it stands about 20 cm (8 in) high. It is 28 to 30 cm (11 to 12 in) in length from the tip of its stout bill to its blunt-ended tail. Atlantic Puffins occur across the North Atlantic from Canada to Norway and south to Spain. The Atlantic puffin is sturdily built with a thick-set neck and short wings and tail.The islands are home to the largest puffin colony in the world, and the keeper, Oskar Sigurdsson, earned a spot in the Guinness Book of World Records for his prolific banding: more than 90,000 birds in that time, including more than 55,000 puffins. A lighthouse keeper on Iceland’s Westman Islands has been banding puffin chicks for more than 60 years.Puffin chicks are known as “pufflings.”.That is why all of our trips are flightless in destination, fully carbon offset - and we have ambitious plans to be net zero in the very near future. We are committed to go as far as possible in curating our trips with care for the planet. ![]() ![]() We know that many of you worry about the environmental impact of travel and are looking for ways of expanding horizons in ways that do minimal harm – and may even bring benefits. Our Sailing Trips invite you to spend a week experiencing the best of the sea and land in the Caribbean and the Mediterranean. Our Mini Trips are small and mighty - they squeeze all the excitement and authenticity of our longer Epic Trips into a manageable 3-5 day window. ![]() Epic Trips are deeply immersive 8 to 16 days itineraries, that combine authentic local experiences, exciting activities and enough down time to really relax and soak it all in. Our Trips are suitable for both solo travellers and friends who want to explore the world together. That is why we have intensively curated a collection of premium small-group trips as an invitation to meet and connect with new, like-minded people for once-in-a-lifetime experiences in three categories: Epic Trips, Mini Trips and Sailing Trips. Increasingly we believe the world needs more meaningful, real-life connections between curious travellers keen to explore the world in a more responsible way. Population size 3.5 mln Life Span 20 yrs TOP SPEED 64 km/h WEIGHT 700-840 g LENGTH 36-40 cm WINGSPAN 74 cm Tufted puffins are colorful seabirds, also known as parrots of the sea that spend winters in the open ocean and return to shore only to breed. We are proud that, for more than a decade, millions like you have trusted our award-winning recommendations by people who deeply understand what makes certain places and communities so special. Culture Trip launched in 2011 with a simple yet passionate mission: to inspire people to go beyond their boundaries and experience what makes a place, its people and its culture special and meaningful - and this is still in our DNA today. Since you are here, we would like to share our vision for the future of travel – and the direction Culture Trip is moving in. ![]() ![]() ![]() He's around level 35, and a ranger mob, which makes him a real pushover. Patriarch Spawn - This is where the minotaur patriarch spawns. He spawns near here, but I don't have any other information on him.ģ. There's also a special froglok spawn named Slaythe the Slayer, who dropped some broken bow quest item or something. If you are camping the patriarch, this is a good place to do it from, otherwise you might lose the patriarch to passer-bys. Three Minotaur Room - 3 Minotaurs spawn in this room. This will take you to the evil eye room (5), from where it is easy to get to any of the other major named spawns.Ģ. The easiest way to get through the maze is to hug the right wall all the way to the jail room (4) and then cut straight through. Be careful here, it's easy to get lost in this maze, and it's alot deadlier than that Cazic Thule maze. Past the (1) marker is the live side maze, which occupies the majority of the live side. Falling off the bridge on the left side is a nice shortcut to the Shin Knight Water Room (13). There is a little know secret wall right before the bridge on the left side that leads to the upper area. This area is mostly Shin Knights, and an occassional Tsu shaman. It's probably best to pull from the maze to here for awhile until the way is clear and you can set up camp elsewhere. This is a pretty nice place to set up, except that you're in the path of any live side trains. Lots of people set up in this area and pull to here. Live Side Entrance Area - This area from the zone to this point is the entrance area of the live side. Not only are the extremely accurate, but they look nice too.ġ. Once again, the best maps of Lower Guk are Quester of Norrath's. They are extremely weak and easy to kill. Rarely a Basilisk will randomly spawn somewhere in Lower Guk. On the dead side, you will find Gargoyles, Black Widows, Vampire Bats, and Greater Ice Bone Skeletons, all of which range from 30-35. These guys are very similar to Wan Knights in ability and level. The most common is the Greater Minotaur, which you can find on the live side of lower guk. There are also many other monsters in Lower Guk. ![]() Jin - Shaman/Wizard Counterparts to the Bok.Kor - Shaman/Wizard Counterparts to the Dar.Yun - Shaman/Wizard Counterparts to the Zol.Urd - Shaman/Wizard Counterparts to the Wan.Tal - Shaman/Wizard Counterparts to the Vis.Tsu - Shaman/Wizard Counterparts to the Shin.Wizards and Shaman at this level are also "Guk" Guk - The most dangerous clan in guk, they range from 45 to 47 I believe.Even at level 50, most classes can't solo them without a pet. These are the bread and butter mobs of this dungeon. Shin - These range from 27 to 31 or so.In Lower Guk, there are a completely different set of clans from Upper Guk. ![]()
![]() Hence, Flashcards are a really handy resource to have and can prove to be extremely useful at every stage of the formative years. So, flashcards can be as simple as single-digit subtraction. So, there are flashcards for number counting to the complex calculations in mathematics that involve formulas. Flashcards are equally beneficial for any age group involving any area of studies such as mathematics, engineering and even medicine. It is usually assumed by people that flashcards are relevant only for early learners. Which age groups do the Flash Cards Benefit? Develops instant memory abilityĪs the child attempts to memorise the answers quickly through the repeated use of flashcards, this leads to an improved ability to memorise things and basic mathematical calculations. With flashcards, the child can just jump on them and practice solving any type of mathematics problem. Reading along the lines in the books can be boring at times. Time Managementįrom a time management perspective, flashcards allow you to take advantage of short amounts of time that become available throughout the day or week, in addition to during planned study sessions. This helps you focus more on the areas that need attention and improve the academic abilities of the child. For instance, you may find that the child is good at addition while he/she is a bit struggling in multiplication. This helps you figure out the strengths as well as the weak areas in mathematics. Moreover, the repetition that is offered through the use of flashcards helps you figure out what information you can remember easily and what needs some amount of additional effort. Recognising the Strong and the Weak Areasįlashcards are often part of spaced practice. A child can make use of flashcards in a timed manner that will help improve the speed as well as efficiency in solving various mathematics problems. They help in improving the efficiency of the child as well. Speed Efficiencyįlashcards are not just portable. All you need is a simple flashcard that displays the question correctly. Moreover, you don’t need flashcards with lots of illustrations to practice a topic. We have read to download flashcards for you which are just a click away. Unlike books, flashcards are not expensive. How about a small game of 10 questions before you start the dinner? Instead of carrying the books or notebooks along when you move out, you can just carry a handful of flash cars which can help your child practice mathematics anywhere. You can carry flashcards anywhere or use them at your convenience, even at your dining table. What is it that makes the use of flashcards relevant in the modern education system as well – Portability Here’s an example that will help understand the working of the flashcards –įlashcards have been used as a practice and memory–aid tool for a long time. This way flashcards can be used not just for improving memory but for practising questions in mathematics as well. So, once the child and answered it, you can check the correctness of the answer and reverse the flash card to show the result to the child as well.When the child is shown the flash card, he / she is supposed ro come up with the answer of the question that has been flashed on the card.One part of the flash card displays the question, for example, it may show up 32 – 5 = _. The use of flashcards involves the following steps – ![]() Let us understand how the flashcards work? How Flash Cards Work?įlashcards are widely used as a learning drill to aid memorization. They are extensively used by teachers in classroom teaching programs to enable children to understand and practice various concepts of different subjects, including mathematics. it is not just the students who benefit from using flashcards. They are an age-old technique that is highly relevant in today’s age as well. Flashcards are not a new concept to learning methodologies. They are, in fact, memory-aid tools intended to help the child memorise various mathematics facts such as addition, subtraction, multiplication, division etc. ![]() How can your benefit the most through the use of flash cards?įlashcards are small two-sided note cards that contain the question on one side and the solution on the other.Which age groups do the Flash Cards Benefit?. ![]() ![]() ![]() ![]() If you want to take your coffee knowledge and experience to the next level, you’ll love trying different exotic types of beans and discovering the unique story behind each harvest. They say you can’t buy happiness, but you can get different single origin beans delivered straight to your door periodically, and that’s kind of the same thing. Why Not Consider a Single Origin Coffee Subscription? If you’d rather sit down and take the time to enjoy the raw and unadulterated taste of coffee, then we are confident you’ll love a single origin (rigorously black, I’d like to emphasize).Ī good place to start – a guide of all the best coffee beans and regions – we have one here. It requires both skill and extensive knowledge ( 1). The next time you get lost in front of the blackboard of your local independent coffee shop, try and spot their house blend.īear in mind that mixing single origin beans is not easy: combining the wrong types might result in a bland or unpleasant taste. If you wish to learn more about blends, here’s where we discussed what a coffee blend is in detail.Ĭoffee roasters create blends to craft a unique, consistent flavor. They can come from different regions within the same geographic area, or from totally separate countries around the world. The majority of coffee blends combine beans that come from two to four places, but some coffee roasters might mix even eight or nine. Single Origin vs Blendsīlends, as the name suggests, are a mixture of coffee beans sourced from different locations and processed together. You can learn more about micro-lot coffee here. It certainly doesn’t get any more exclusive than this. The finest coffee connoisseurs can purchase beans that come from a particular lot (or an even smaller nano-lot) in a specific farm. Since some farms aren’t big enough to supply satisfying amounts of coffee, it’s common to find beans that come from the same cooperative instead. Because it’s bound to a harvesting season and has very limited availability, it’s more expensive, but also of very high quality. Shaped by the levels of rain, farmers’ traditions, specific growing conditions and processing methods, this coffee is a unique product of that particular time and place. These are beans that are grown within a single farm. As an example: a ‘Peruvian coffee bean’ is a single origin, but a bean from a certain farm in Peru is also single origin. ![]() ![]() ![]() ![]() ![]() The LPM swell method for two beams from two sites scenario was found to be the most accurate in estimating swell parameters (RMS Error of 0.24m), the inverted swell height correlated well with the partitioned in situ swell measurements. The methods were evaluated using (1) a single beam from a single radar site, (2) two beams from a single radar site, and (3) two beams from two radar sites intersecting each other at the buoy location. (2016), and an empirical method, denoted as LPM, WFG, and EMP respectively are presented and evaluated. To examine the influence of swell, three different swell inversion models developed by Lipa et al. Within the radar footprint, in situ wave spectra were collected using a buoy deployed offshore of the north coast of Cornwall in the UK, and used for comparisons. Doppler spectra from single beam/site and two beams/sites WERA HF radar system operated with frequency 12 MHz are used over a one-month (March 30th-April 27th, 2012) data collection. The ability of the method to estimate wave directional spectra and bulk wave parameters from inverting Doppler spectra are investigated. The applicability of the empirical wave inversion method to increase the accuracy of the estimation of ocean wave spectra and wave bulk parameters by accounting for the presence of swell waves is examined and presented. This is further confirmed using data from 12 MHz system sampling ocean conditions with significant swell energy being present at times. Application of the weighting function in the wind wave inversion model results in empirical wind-wave regression coefficient that is not wave frequency-dependent and of similar in magnitude to those found in studies that used different radar operating frequencies but included the weighting function in the inversion. However, at lower operating frequencies the normalization removes some of the wind wave energy something that needs to be accounted for. This removes no wind-wave energies from the second harmonic and corner reflection peaks and leads to better wave estimations. Using a single VHF (48 MHz) covering the nearshore and in situ directional wave data from ranges between 0.7 and 4.2 km and beam angles between 22.3 and 55.8 deg, it was concluded that wind wave inversion of the 2nd order spectra requires normalization by using Barrick’s (1977b) weighting function. Further, most research on HF radar wave inversion has been limited todissertation, a hybrid radar wave inversion method that treats swell and wind waves separately is introduced and evaluated using a single Very High Frequency (VHF) 48 MHz radar site, two High Frequency (HF) 12 MHz radar sites, and in situ wave measurements. A number of theoretical and empirical inversion methods have been developed to estimate wave parameters from the HF radar data, with the latter one being more attractive for routine operations due to easier implementation and reduced computational cost. Estimation of surface currents is based on analyzing the signal of the first-order Bragg peak, while extraction of wave information requires analysis of the signal contained in the second-order continuum of the Doppler spectra its quality depends on a number of environmental (i.e., noise levels, ocean wave energy) and system-based (i.e., frequency of operation, range, azimuthal angle, etc.) parameters. Although High Frequency (HF) radars are used routinely for measuring ocean surface currents at high spatial and temporal resolution, their utilization for estimating ocean wave spectra is still limited, mainly because of the lack of extensive evaluation of the accuracy of wave inversion models, and lack of well-established methods, especially if swell is present in the area of study. ![]() ![]() ![]()
![]() ![]() ![]() 7 In addition, the randomized, placebo-controlled, phase 3 KEYNOTE-407 study showed significantly improved OS and PFS with pembrolizumab plus carboplatin and paclitaxel or nab-paclitaxel versus placebo plus chemotherapy in patients with stage IV squamous NSCLC. 6 The randomized, placebo-controlled, phase 3 KEYNOTE-189 study, a larger confirmatory clinical trial, demonstrated significantly improved overall survival (OS) and progression-free survival (PFS) with pembrolizumab plus pemetrexed and carboplatin or cisplatin versus placebo plus chemotherapy in patients with metastatic nonsquamous NSCLC without sensitizing EGFR or ALK alterations. In cohort G of the multicohort, phase 1/2 KEYNOTE-021 study, a significantly higher objective response rate (ORR) was observed with pembrolizumab plus pemetrexed and carboplatin versus chemotherapy alone in patients with previously untreated advanced nonsquamous NSCLC and no sensitizing EGFR or ALK alterations. 4, 5 Chemotherapy may also enhance the antitumor activity of immunotherapy 4 and thus increase the likelihood of a clinical benefit with pembrolizumab, regardless of tumor PD-L1 expression. On the basis of results from KEYNOTE-001, patients with PD-L1‒negative tumors (PD-L1 TPS < 1%) were not included in these studies, and they are not eligible for pembrolizumab monotherapy.Ĭhemotherapy agents have shown immunomodulatory properties, including directly and indirectly stimulating immune responses and increasing tumor immunogenicity. 1 Results from the phase 3 studies KEYNOTE-024 and KEYNOTE-042 for patients with PD-L1 expression on ≥50% of tumor cells (tumor proportion score ≥ 50%) 2 and for patients with a PD-L1 TPS ≥ 1%, 3 respectively, subsequently established pembrolizumab monotherapy as a first-line standard of care for patients with PD-L1‒positive advanced NSCLC and no EGFR or ALK genomic tumor aberrations. The anti–programmed death 1 (PD-1) monoclonal antibody pembrolizumab first showed increasing clinical efficacy with higher levels of programmed death ligand 1 (PD-L1) expression inpatients with advanced non–small cell lung cancer (NSCLC) in the phase 1b KEYNOTE-001 study. Pembrolizumab plus chemotherapy demonstrated response and survival improvements with manageable safety in comparison with chemotherapy alone in PD-L1‒negative advanced/metastatic NSCLC, and it is a standard-of-care first-line therapy for patients with advanced NSCLC, regardless of PD-L1 expression. Adverse events (AEs) were experienced by 99.2% of the patients who received pembrolizumab plus chemotherapy and by 98.9% of the patients who received chemotherapy alone, with grade 3 or higher AEs occurring in 71.4% and 72.0%, respectively immune-mediated AEs and infusion reactions were experienced by 29.0% and 12.4%, respectively. ![]() Sixteen patients in the pembrolizumab plus chemotherapy arm completed 2 years of treatment the objective response rate was 87.5% (95% CI, 61.7%-98.4%), and the 3-year OS rate was 100%. Pembrolizumab plus chemotherapy improved overall survival (OS hazard ratio, 0.63 95% CI, 0.50-0.79) and progression-free survival (HR, 0.68 95% CI, 0.56-0.83) over chemotherapy. The median time from randomization to the data cutoff was 28.0 months (range, 14.7-55.4 months). Resultsįour hundred forty-four of the 1328 patients (33.4%) who were enrolled across the 3 trials had PD-L1‒negative tumors (256 on pembrolizumab plus chemotherapy and 188 on chemotherapy alone ). ![]() No α was assigned to this descriptive, exploratory analysis. Responses were assessed according to Response Evaluation Criteria in Solid Tumors version 1.1 by blinded, independent, central review. Treatment comprised pembrolizumab plus chemotherapy (pemetrexed and platinum for nonsquamous histology and carboplatin and paclitaxel/nab-paclitaxel for squamous histology) or chemotherapy alone. Individual patient data were pooled from KEYNOTE-021 cohort G (nonsquamous NCT02039674), KEYNOTE-189 (nonsquamous NCT02578680 and NCT03950674), and KEYNOTE-407 (squamous NCT02775435). This study pooled data from 3 randomized controlled trials to evaluate outcomes with pembrolizumab plus chemotherapy versus chemotherapy alone in patients with advanced/metastatic NSCLC negative for PD-L1 (ie, a tumor proportion score < 1%). Pembrolizumab plus platinum-based chemotherapy has demonstrated improved clinical outcomes over chemotherapy alone in patients with previously untreated advanced/metastatic non–small cell lung cancer (NSCLC), regardless of tumor programmed death ligand 1 (PD-L1) expression. ![]() |
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